​Ferroptosis

  • A recent study by researchers has identified ferroptosis, an unusual form of cell death, as a significant contributor to lung damage in COVID-19 patients.
  • Ferroptosis results from iron accumulation and lipid peroxidation in cells.
  • It involves depletion in the antioxidant enzymes resulting in lipid peroxidation and oxidative stress.
  • It is an iron-dependent and oxidative damage induced cell death involving cytological changes such as decreased mitochondrial cristae and damaged mitochondrial membranes.
  • These cell abnormalities resulted from the loss of selective permeability of plasma membrane due to intense membrane lipid peroxidation and the occurrence of oxidative stress.
  • Ferroptosis is an exceptional metabolic process involving amino acids, lipids, ....
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