Ferroptosis
- A recent study by researchers has identified ferroptosis, an unusual form of cell death, as a significant contributor to lung damage in COVID-19 patients.
- Ferroptosis results from iron accumulation and lipid peroxidation in cells.
- It involves depletion in the antioxidant enzymes resulting in lipid peroxidation and oxidative stress.
- It is an iron-dependent and oxidative damage induced cell death involving cytological changes such as decreased mitochondrial cristae and damaged mitochondrial membranes.
- These cell abnormalities resulted from the loss of selective permeability of plasma membrane due to intense membrane lipid peroxidation and the occurrence of oxidative stress.
- Ferroptosis is an exceptional metabolic process involving amino acids, lipids, ....
