Key Cellular Mechanism in Huntington Disease Discovered
A team of scientists from National Centre for Cell Science (NCCS), Pune, and Savitribai Phule Pune University (SPPU) has discovered a key cellular mechanism in Huntington disease (HD) - a progressive genetic disorder which affects the brain.
HTT Gene and the Cellular Mechanism
- The scientists studied the cellular mechanism of the disease in fruit flies.
- Huntington disease is caused by a mutation in a gene called HTT. This gene is involved in the production of a protein called Huntingtin.
- Mutation in HTT gene leads to production of abnormal Huntingtin proteins which form clumps. The clumps disrupt several cellular processes and prevent ....
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