Miniature TnpB-based Genome Editing Tool

Recently, Indian researchers created a hypercompact genome-editing system using TnpB proteins, offering a homegrown alternative to proprietary CRISPR-Cas technologies.

What is the TnpB-based Genome Editing System?

  • TnpB (Transposon-associated protein) is a tiny, next-generation genome-editing enzyme that works like CRISPR but is far more compact.
  • It functions as a molecular scissor, cutting plant DNA at a precise target location guided by a matching RNA sequence.

Key Features and Advantages

  • Hypercompact Size: TnpB has only 400–500 amino acids, compared with 1,000–1,400 in Cas9 and ~1,300 in Cas12a.
  • Easy Delivery: Its small size enables viral vector delivery directly into plant cells, eliminating the need for ....
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