Regulatory T-cells (Tregs) and the Foxp3 gene
Regulatory T-cells (Tregs) are a specialized sub-population of white blood cells that act as the "peacekeepers" of the immune system, preventing it from attacking the body’s own healthy tissues. The Foxp3 gene serves as the "master switch" or genetic controller that determines the development and functional program of these suppressor cells.
How Tregs Work
- Genetic Programming: The Foxp3 gene is activated in certain T-cells in the thymus. This activation "reprograms" the cell into a Regulatory T-cell.
- Immune Suppression: Once active, Tregs circulate in the body and detect "overactive" immune cells. They release inhibitory chemicals (cytokines) like Interleukin-10 (IL-10) to calm the ....
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