Brain Circuit Linked to Chemotherapy-Induced Cold Allodynia

Recently, researchers from IISc Bengaluru and The Chatterjee Group Centres for Research and Education in Science and Technology (TCG CREST) identified a brain circuit associated with chemotherapy-induced cold allodynia in mice.

What is Cold Allodynia?

  • Cold allodynia is a condition in which normal cold temperatures cause pain or distress.
  • Chemotherapy Side Effect: It is associated with chemotherapy-induced peripheral neuropathy (CIPN).
  • Common Drug: It is particularly associated with oxaliplatin, a platinum-based chemotherapy drug.
  • Other Causes: Viral infections, injuries and diabetes can also cause cold allodynia.

How Does the Brain Circuit Cause Cold Allodynia?

  • Brain Circuit: The connection between the lateral parabrachial nucleus (LPB) and ....
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