Key Gene Mutations Driving Oral Cancer in Women Identified

Recently, Indian scientists uncovered critical gene mutations linked to oral cancer among women in southern India, offering important insights into a disease that poses a significant public health challenge.

• The study examined female patients with a history of chewing tobacco-infused betel quid, a major risk factor for oral cancer in southern and northeastern India.
• Whole-exome sequencing of tumour samples from 38 women revealed ten significant gene mutations.
• CASP8 emerged as a potential driver mutation in women, differing from patterns seen in male-focused studies, while co-occurring TP53 and CASP8 mutations were linked to aggressive and recurrent ....