p47 Protein: Protecting Cells against Mechanical Stress

In September 2025, a groundbreaking study by researchers at the S. N. Bose National Centre for Basic Sciences (SNBNCBS, Kolkata), an autonomous institute under the Department of Science and Technology, revealed the protective role of a lesser-known protein, p47, in maintaining protein stability under mechanical stress.

Mechanical Stress in Cells: The Hidden Challenge

Proteins in living cells constantly experience mechanical forces as they are pulled, twisted, and compressed during vital processes such as:

  • Transport within the cell
  • Protein degradation
  • Cytoskeletal remodelling

These forces affect how proteins fold, unfold, and function. While canonical chaperones have been widely studied for their role in guiding protein folding, ....

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