Study Reveals How Cell Microenvironment Stiffness Affects Tissue Form

Recently, an interdisciplinary research team from the Indian Institute of Science (IISc) has revealed the impact of a cell's microenvironment stiffness on its structure and function, offering insights into tissue healing and scar formation.

  • Inefficient wound healing can lead to tissue fibrosis and scar formation, with implications for conditions like cardiac arrest and diseases such as cancer.
  • Changes in stiffness influenced cell structure and function, with fibroblasts on less stiff substrates showing rounder shapes, altered cytoskeleton protein levels, cell cycle arrest, reduced growth rates, and cell death.
  • The research focused on Transforming Growth Factor-β (TGF-β) as the master regulator ....
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