Scientists discover Brown Fat ‘Switch’
In May 2026, scientists discovered a hidden molecular mechanism that activates calorie-burning brown fat, a breakthrough that could aid future treatments for metabolic disorders and bone diseases.
- Researchers identified a hidden molecular “switch” that activates an alternative heat-producing system in brown fat.
- Brown fat burns calories to generate heat and helps regulate metabolism and body temperature.
- Scientists found that glycerol, released when fat breaks down during cold exposure, activates the process.
- Glycerol binds to a specific “glycerol pocket” in the Tissue-nonspecific alkaline phosphatase (TNAP) enzyme, triggering the heat-producing mechanism.
- The discovery explains activation of the “futile creatine cycle,” an alternative ....
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