​CSIR Scientists Unveil Advanced Genome-Editing Tool

Recently, scientists at Council of Scientific & Industrial Research-Institute of Genomics and Integrative Biology (CSIR-IGIB) in New Delhi have developed an enhanced genome-editing system that surpasses current CRISPR technologies in precision and efficiency.

Enhanced Precision with FnCas9

  • Superior Targeting: The new system utilizes an engineered version of the FnCas9 enzyme from the bacterium Francisella novicida. Adjustments to amino acids in FnCas9 have improved its binding affinity to the protospacer-adjacent motif (PAM) sequence on DNA, making gene editing more accurate.
  • Reduced Off-Target Effects: Unlike traditional CRISPR-Cas9, which can cause unintended genetic alterations, the enhanced FnCas9 minimizes off-target effects, increasing its reliability for ....
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