dbGENVOC: World’s First Database of Genomic Variants of Oral Cancer

• 09 Jul 2021

DBT-National Institute of Biomedical Genomics (NIBMG), Kalyani an Autonomous Institute funded by the Department of Biotechnology, Government of India has created a database of genomic variations in oral cancer; the first of its kind in the world.

• dbGENVOC is a browsable online database of GENomic Variants of Oral Cancer and is a free resource.
• dbGENVOC is not just a catalogue of genomic variants, it has a built-in powerful search engine. It also allows a reasonable extent of statistical and bioinformatic analysis to be carried out online, including identifying variants in associated altered pathways in oral cancer.
• The repository, which will be updated annually with variation data from new oral cancer patients from different regions of India and southeast Asia, has the potential to support advances in oral cancer research and will be a major step in moving forward from simply cataloguing variants to gain insight into their significance.
• Oral cancer is the most prevalent form of cancer among men in India, largely fuelled by tobacco-chewing. Tobacco-chewing causes changes in the genetic material of cells in the oral cavity. These changes (mutations) precipitate oral cancer.

About NIBMG

• The National Institute of Biomedical Genomics (NIBMG) has been established as an autonomous institution by the Government of India, under the aegis of the Department of Biotechnology.
• This is the first institution in India explicitly devoted to research, training, translation & service and capacity-building in Biomedical Genomics. It is located in Kalyani, West Bengal, India, near Kolkata.