New Nanomaterial for Non-Invasive Brain Therapy

In September 2025, researchers from the Institute of Nano Science and Technology (INST, Mohali), under India’s Department of Science and Technology, announced a breakthrough nanomaterial that can directly interact with neurons, opening possibilities for non-invasive treatments of brain disorders.

Key Points

The New Nanomaterial: The researchers identified graphitic carbon nitride (g-C₃N₄) as capable of naturally interacting with neurons, supporting their growth, maturation, and communication.
Research Findings: The study showed that g-C₃N₄ boosted dopamine levels in lab-grown brain-like cells and reduced harmful proteins linked to Parkinson’s disease in animal models.
Non-Invasive Advantage: Unlike deep brain stimulation that requires surgery or limited magnetic/ultrasound techniques, g-C₃N₄ provides therapeutic effects without invasive procedures.
Mechanism of Action: The nanomaterial generates tiny electric fields in response to brain activity, which activate calcium channels in neurons to promote stronger growth and connectivity.
Scientific Breakthrough: This marks the first instance of semiconducting nanomaterials directly modulating neurons without external stimulation, opening new directions in brain therapy.
Smart Switch Function: The material acts like a switch, turning “on” under negative membrane potential to stimulate neurons and “off” under positive potential to prevent fatigue.