Nanotech Tool for Early Parkinson’s Detection

In August 2025, scientists at the Institute of Nano Science and Technology (INST), Mohali, announced the development of a nanotechnology-based biosensor capable of detecting Parkinson’s Disease (PD) in its earliest stages, offering hope for timely diagnosis and intervention.

Key Points

Focus on α-Synuclein: The study concentrated on the protein α-synuclein, which normally remains harmless but in Parkinson’s patients forms toxic aggregates that damage brain cells.
Gold Nanocluster Innovation: Researchers designed glowing gold nanoclusters coated with amino acids to selectively detect different forms of the protein linked to PD.
Selective Binding: Proline-coated nanoclusters bound to the healthy protein, while histidine-coated nanoclusters targeted the toxic aggregated form, allowing precise distinction between the two.
Potential Impact: The biosensor may enable detection of Parkinson’s before symptoms manifest, reducing healthcare costs and improving quality of life for patients.
Wider Applications: Researchers believe the same platform could be adapted for early detection of other neurodegenerative diseases, including Alzheimer’s.