RRI Develops Novel Dual-Trap Optical Tweezers System

• 27 Sep 2025

In September 2025, researchers at the Raman Research Institute (RRI) unveiled a breakthrough dual-trap optical tweezers system, offering unprecedented precision and versatility for manipulating single biomolecules and microscopic particles.

Key Points

• Next-Generation Optical Tweezers: Builds on the Nobel Prize-winning technology (2018) that uses light to manipulate microscopic objects and measure ultra-small forces.
• Confocal Detection Scheme: Each detector monitors only the light scattered from its own trap, eliminating signal interference and enabling stable, long-duration experiments.
• Seamless Integration: The design removes cross-talk and works compatibly with phase contrast and fluorescence microscopy, integrating effortlessly with standard microscopes.
• Compact and Modular Design: Functions as a single plug-and-play module, allowing researchers to add it to existing microscopes without altering their structure.
• Enhanced Research Applications: Facilitates high-precision force measurements, single-molecule studies, and biological sample manipulation in neuroscience, drug discovery, and medical research.
• Patent and Commercialization Plans: The system is under consideration for patent protection and is expected to be commercialized to make advanced tools more accessible to Indian scientists.